BoNTA works by blocking the neuromuscular junctions around the injection sites. This prevents targeted muscles from contracting and hence the targeted muscle relaxes. With prolonged relaxation of the targeted muscles, loss of muscle volume may then occur, which is the treatment target in some areas.

BoNTA wrinkle treatment may kick in from 12 hours to 1 week after injection, with an average time-to-effect of 2 to 3 days. For muscle slimming, this may take anywhere between 1 to 4 weeks, depending on the size of the muscle and the dosage used.

Each treatment is expected to last between 3 to 6 months in duration – typically as one is exposed to more BoNTA treatments, the effective duration of each treatment tends to shorten.

BoNTA can be used to treat:

Dynamic Wrinkles

• dynamic lines around the eyes, commonly known as crow’s feet
• dynamic lines between the eye brows, commonly known as frown lines
• dynamic lines over the forehead
• dynamic lines around the nose, commonly known as bunny lines

Hypertrophic Muscles

• reduction of jaw (masseter) muscle for facial slimming and/or bruxism
• reduction of platysmal muscles of the neck/improve neckline definition
• reduction of shoulder blade or calf muscles (off-label)

Dermalift

BoNTA can also be administered along the facial and neck contours in multiple small injections intradermally (into the skin), known as a Dermalift.

Excessive Sweating

BoNTA can also be used to treat conditions of excessive sweating, in particular the axilla.

Medical contra-indications aside, not all wrinkles can be treated effectively with BoNTA. As BoNTA works primarily on relaxing the muscles, dynamic wrinkles are the main focus of treatment, and fixed/static wrinkles (i.e. present without making any expression) may not respond to BoNTA treatment.

Some individuals may also develop treatment resistance to BoNTA especially after repeated exposure. This may be partial (whereby a partial therapeutic response is observed with standard doses) or complete (whereby no response is observed even with supra-therapeutic doses). Treatment resistance may or may not be associated with neutralizing antibodies to BoNTA, and isn’t fully understood.

It is common for individuals to notice that their effective duration of BoNTA decreases with repeated exposures, some to as short as 1 to 2 months of duration. Unfortunately, not much can be done apart to increase the dosages administered, or to administer more frequent treatments.

Before commencing any BoNTA treatment, one ought to know the potential side effects.

BoNTA side effects are by and large due to its local effects:

Direct Effect – Targeted Muscle

This may manifest itself as the sensation of stiffness, most commonly noticed when receiving BoNTA injections for the first time.

Direct Effect – Adjacent Muscle

For BoNTA injections around the eye, spread of the BoNTA may result in brow depression and/or upper eyelid depression (ptosis). Rarely, spread of BoNTA into the eye muscles may result in a squint or affect the vision.

BoNTA injections to the jaw muscles may result in an asymmetric smile due to the involvement of the muscles involved in smiling on one side of the face.

Secondary Effect – Muscle Volume Loss

BoNTA to the jaw muscles for jaw/masseter reduction is intended to induce muscle volume loss. However, some individuals may appear gaunt/haggard as a result, and the cosmetic outcome may not be ideal.

Duration of Side Effects

BoNTA only has a maximum effect of 6 months in duration and any side effects are expected to disappear by then.

BoNTA when used in cosmetic dosages does not cause generalized paralysis or breathing difficulties. Hence, cosmetic BoNTA does not kill, unless one has an extremely rare case of anaphylactic reaction to BoNTA.

There was an unfortunate incident of a young lady who died after intravenous treatment locally, which was wrongly attributed to BoNTA n the initial press releases, but subsequently clarified to be unrelated.

Overseas, deaths from BoNTA have been documented due to the use of unlicensed BoNTA products manufactured illegally, which contained many times the normal dosages of BoNTA.

In short, cosmetic BoNTA does not kill.